Exploratory Study of MRI Biomarkers of NASH

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Metabolic steatosis disease (NAFLD) is a rapidly growing disease in the world, particularly in industrialized countries. NAFLD is defined by the presence of fatty liver disease. This is a reversible phenomenon that can be estimated by non-invasive means, such as ultrasound. Non-invasive quantification, on the other hand, requires MRI. Nonalcoholic steatohepatitis (NASH) is the aggressive form of the disease that promotes the accumulation of fibrosis in the liver, which can progress to cirrhosis and its complications. Currently there is no non-invasive biomarker of NASH and the diagnosis is based solely on liver biopsy. There is therefore a need for non-invasive biomarkers of NASH in patients with steatosis to diagnose NASH without the use of liver biopsy.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Patient included in the SNIFF cohort of the Angers hospital where there is a suspicion of NASH requiring a biopsy for which an MRI is requested by a hepatologist as part of the initial assessment of the disease.

• Adult patient

• Free, informed and express (oral) consent of the patient to participate in the study

Locations
Other Locations
France
University Hospital, Angers
RECRUITING
Angers
Contact Information
Primary
Anita PAISANT, MD
anita.paisant@chu-angers.fr
0241353637
Backup
Anthéa LOIEZ
anthea.loiez@chu-angers.fr
0241353637
Time Frame
Start Date: 2025-09-05
Estimated Completion Date: 2027-09-06
Participants
Target number of participants: 60
Treatments
Experimental: Open label
Related Therapeutic Areas
Sponsors
Leads: University Hospital, Angers
Collaborators: University Angers

This content was sourced from clinicaltrials.gov